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Description
BAFF Recombinant Rabbit mAb (S-2175-109)Product Specification Host Rabbit Antigen BAFF Synonyms Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator (BLyS); B cell activating factor; BAFF; Dendritic cell derived TNF like molecule; TNF and APOL related leukocyte expressed ligand 1 (TALL 1); CD257; BLYS; TALL1; TNFSF20; ZTNF4; TNFSF13B Immunogen Recombinant Protein Location Cell membrane Accession Q9Y275 Clone Number S 2175 109 Antibody Type Recombinant mAb Isotype IgG
Product Specification
| Host | Rabbit |
| Antigen | BAFF |
| Synonyms | Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator (BLyS); B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1 (TALL-1); CD257; BLYS; TALL1; TNFSF20; ZTNF4; TNFSF13B |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q9Y275 |
| Clone Number | S-2175-109 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | HL-60, U-937 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu |
Background
BAFF (B-cell activating factor), encoded by TNFSF13B and also known as BLyS or CD257, is a 285-aa type-II transmembrane glycoprotein of the TNF ligand superfamily produced by monocytes, dendritic cells, macrophages and activated T cells that can be cleaved to a soluble homotrimeric cytokine which, via engagement of three receptors—BAFF-R, TACI and BCMA—delivers survival and maturation signals to B cells, orchestrates T-cell co-stimulation, and drives class-switching and antibody production through NF-κB and PI3K/AKT pathways, while excess BAFF triggers B-cell hyperplasia and autoantibody formation, linking its overexpression to systemic lupus erythematosus, Sjögren syndrome, rheumatoid arthritis and multiple myeloma, and making BAFF antagonism (e.g., belimumab) a validated therapeutic strategy.
Shipping Notes
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Exchange/Return Notes
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