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Description
MFF Recombinant Rabbit mAb (S-2330-28)Product Specification Host Rabbit Antigen MFF Synonyms Mitochondrial fission factor; C2orf33 Immunogen Synthetic Peptide Location Mitochondrion Accession Q9GZY8 Clone Number S 2330 28 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt Positive Sample MCF7, DU 145, A549, HeLa, T 47D, mouse brain, rat brain Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | MFF |
| Synonyms | Mitochondrial fission factor; C2orf33 |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | Q9GZY8 |
| Clone Number | S-2330-28 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | MCF7, DU 145, A549, HeLa, T-47D, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
MFF (Mitochondrial Fission Factor) is an evolutionarily conserved, tail-anchored outer-mitochondrial-membrane receptor that serves as the principal platform for recruiting the cytosolic GTPase Drp1 to sites of future organelle division, thereby initiating the oligomerization of Drp1 into a helical collar that constricts and finally severs the mitochondrion in a GTP-driven reaction, while also integrating peroxisomal fission, controlling mitochondrial size, number and distribution, and acting as a crucial node for post-translational and lipid-mediated signals that tune the balance between fission and fusion in response to metabolic stress, cell-cycle cues and pathological stimuli such as those observed in cancer and cardiovascular disease.
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