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Description
PICK1 Recombinant Rabbit mAb (S-2346-165)Product Specification Host Rabbit Antigen PICK1 Synonyms PRKCA binding protein; Protein interacting with C kinase 1; Protein kinase C alpha binding protein; PRKCABP Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Synapse Accession Q9NRD5 Clone Number S 2346 165 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, NIH 3T3, C6, COS 7, C2C12, mouse brain, rat brain Predicted Reactivity Bv,
Product Specification
| Host | Rabbit |
| Antigen | PICK1 |
| Synonyms | PRKCA-binding protein; Protein interacting with C kinase 1; Protein kinase C-alpha-binding protein; PRKCABP |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Synapse |
| Accession | Q9NRD5 |
| Clone Number | S-2346-165 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, NIH/3T3, C6, COS-7, C2C12, mouse brain, rat brain |
| Predicted Reactivity | Bv, Or |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
Protein Interacting with C Kinase 1 (PICK1) is a 416-residue peripheral membrane scaffolding protein encoded by the PICK1 gene, comprising an N-terminal PDZ domain that binds the C-termini of membrane proteins such as AMPA-receptor subunits GluA2/3, dopamine transporter and acid-sensing ion channels, a central BAR domain that senses and induces membrane curvature, and a C-terminal acidic region; through PDZ-mediated interactions it clusters and traffics glutamate receptors to and from synapses, thereby regulating excitatory synaptic strength and plasticity underlying learning and memory, while its BAR domain cooperates with actin and endocytic machinery to control clathrin-mediated endocytosis, synaptic-vesicle recycling and dense-core vesicle biogenesis, and disruption of PICK1 in mice leads to impaired long-term depression, male infertility and neurotransmission deficits .
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