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Description
FITC Mouse Anti-Human Granzyme B Antibody (S-3342)Product Specification Host Mouse Antigen Granzyme B Synonyms C11; CTLA 1; Cathepsin G like 1 (CTSGL1); Cytotoxic T lymphocyte proteinase 2 (Lymphocyte protease); Fragmentin 2; CGL1; CSPB; CTLA1; GRB; GZMB Location Secreted Accession P10144 Clone Number S 3342 Antibody Type Mouse mAb Isotype IgG1,k Application ICFCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation FITC Physical Appearance Liquid
Product Specification
| Host | Mouse |
| Antigen | Granzyme B |
| Synonyms | C11; CTLA-1; Cathepsin G-like 1 (CTSGL1); Cytotoxic T-lymphocyte proteinase 2 (Lymphocyte protease); Fragmentin-2; CGL1; CSPB; CTLA1; GRB; GZMB |
| Location | Secreted |
| Accession | P10144 |
| Clone Number | S-3342 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | ICFCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 5μl per million cells in 100μl volume | Hu |
Background
Granzyme B is a 32-kDa serine protease stored in the cytolytic granules of cytotoxic T lymphocytes and natural killer cells, whose immune function centers on perforin-assisted translocation into target cells where it directly cleaves and activates pro-apoptotic substrates such as procaspase-3, Bid and PARP, thereby igniting both caspase-dependent and caspase-independent mitochondrial apoptosis pathways to eliminate virus-infected or malignant cells.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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4.2 ★★★★★
Based on 2165 reviews
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Product Reviews
★★★★★ 5
Great for Mega Chewer
Flavor Name: Bacon, Size: X-Large
Got one of these for our Rodesien Ridgeback when he was a puppy, and it worked well. So, when my daughter rescued two medium-sized dogs (one is an Australian Cow dog mix, and the other a Plott Hound mix) it was a no-brainer. The Plott Hound mix has jaws of steel and destroys anything and everything he can get his mouth around, except items from this maker. This is the only toy brand I've found that he doesn't demolish in under 5 minutes. Oh, and I'm stunned he can put bite marks in it. The Rodesien Ridgeback didn't even do that when he was a puppy, so I was surprised. However, that being said, the toy is holding up to hours of abuse. I had to buy additional toys because they don't like to share.
Update on 01/09/20: these are still holding up to repeated abuse.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 21, 2019
★★★★★ 4
Sensational Toy By Nylabone Keeps Your Best Freinds Teeth Snow White!
Flavor Name: Bacon, Size: X-Large
Our Bull dogs LOVE these bones. Long time Nylabone fans they've been making quality dog toys here in the United States for over fifty years.
The nubs on the end of the bone age great for cleaning teeth and massaging bones. The center is softer but still holds up to even the toughest aggressive chewers. For whatever reason this isn't a "favorite" toy in the sense that they drag it around a few hours a day but they do play with it and we replace them when the ends start to shred - which should be done with all nylabone chew toys.
The price on Amazon is virtually half the cost of the big box pet stores so it's affordable - not to mention fun to replace their toys and try new ones often. Plus with a Prime membership almost every item we buy ships with Free two day shipping - making the deals even that much sweeter.
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Reviewed in the United States on December 16, 2012
★★★★★ 5
You've got to be kidding. Really !!!
Flavor Name: Bacon, Size: X-Large
I've used these for over fifteen years They are great. But, mine only lasted two days this time. Lucy the Labrador, left it in the driveway one afternoon. The next morning a huge garbage truck ran over it, making dust out of it. Normally, Lucy cant go any ware without it, so leaving it outside was her fault. And mine, for not checking. Yes, I ordered another one right away. Otherwise, she would have drove me crazy. These are great, and they last a long time, even with the most aggressive chewers. Lucy, passed away on June 16, at age 13, but you can bet I still have her favorite bone. The more a dog chews on these, the better they brush the dogs teeth. A+ product, just like their other items.
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Reviewed in the United States on June 30, 2015
★★★★★ 5
Large, Heavy, DURABLE!
Flavor Name: Bacon, Size: Medium
This bone is probably too big and heavy for my medium size cocker spaniel. But I bought it anyway, because he was able to demolish the Nylabones that were labeled "for medium dogs".
He can still pick this one up and carry it around, but he cannot fit an entire end into his mouth. Still, he loves it--he's greedy and relishes the fact that he has such a big bone all for himself. He even sleeps with it!
I like it because of the fact that it doesn't completely fit into his mouth. Due to this, the bone has lasted much longer than all the other Nylabones I bought him in the past. And because he can't shred this one, I don't find sharp bit of Nylabone fragments everywhere and it doesn't make his gums bleed either.
I happy I found this and will continue buying oversized Nylabone toys for my dog!
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Reviewed in the United States on March 21, 2012
★★★★★ 5
Durable
Flavor Name: Bacon, Size: X-Large
My dog loves these, we used to get him one size smaller. But after a month or so he would have the end knuckle chewed open trying to get at the inside. This one here he chews on it all day and hasn't put a dent in it. Great dog bone.
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Reviewed in the United States on June 3, 2024
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