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Description
NMNR™ Pro Synergy - 90 capsulesFinally, NMN and NR Together NMN and NR elevate NAD+ through complementary pathways*1,2 Powers cellular energy to support brain, heart, and whole body vitality*3 5 Enhances mitochondrial performance and resilience with age*3 5 Includes TMG to support balanced methylation*6 Addresses key drivers of healthy aging*2,7 View Certificate of Analysis The Next Evolution in NAD+ Science NMNR Pro Synergy unites NMN and NR in one advanced formula designed to
Finally, NMN and NR Together
- NMN and NR elevate NAD+ through complementary pathways*1,2
- Powers cellular energy to support brain, heart, and whole-body vitality*3-5
- Enhances mitochondrial performance and resilience with age*3-5
- Includes TMG to support balanced methylation*6
- Addresses key drivers of healthy aging*2,7
The Next Evolution in NAD+ Science
NMNR™ Pro Synergy unites NMN and NR in one advanced formula designed to restore and sustain cellular NAD+ levels. This dual-precursor approach fuels energy production, supports DNA repair, and promotes cellular revitalization. With added TMG to maintain methylation balance, the formula delivers comprehensive, long-term support for healthy aging and vitality.*1-7
How It Works
This formula is designed to help restore NAD+ through three complementary mechanisms.
-
NMN (Nicotinamide Mononucleotide)
NMN is an immediate precursor to NAD+ that bypasses early rate-limiting steps in the salvage pathway. It supports rapid increases in intracellular NAD+, helping energize mitochondria and activate sirtuin enzymes involved in cellular repair and longevity.*3,4 -
NR (Nicotinamide Riboside)
NR complements NMN by supporting systemic NAD+ synthesis through distinct transport and conversion pathways. Hydrogen malate enhances NR bioavailability and provides malic acid, a key component of the Krebs energy cycle.*2,8 -
Trimethylglycine (TMG)
TMG provides methyl groups needed to recycle homocysteine into methionine, supporting balanced methylation and maintaining NAD+ homeostasis. It also protects against the potential depletion of methyl donors during NAD+ synthesis from NMN and NR.*6
Together, these clinically studied ingredients help restore healthy NAD+ levels and strengthen the body’s natural capacity for energy, repair, and resilience.*1-5
Why NAD+ Matters
Nicotinamide Adenine Dinucleotide (NAD) is a vital coenzyme present in every cell, essential for creating and maintaining energy throughout the body. Each human cell contains hundreds of millions of NAD+ molecules that power metabolism, drive DNA repair, and activate key enzymes like PARPs and sirtuins, which sustain cellular integrity, stress resilience, and healthy aging.9,10
As we age, NAD+ levels naturally decline. This reduction diminishes mitochondrial energy production and weakens the activity of sirtuins, PARPs, and AMPK, leaving cells more susceptible to damage. The decline is further accelerated by increased CD38 activity — an enzyme that degrades NAD+ and disrupts energy balance.9,10
Restoring NAD+ levels with precursors such as NMN and NR, complemented by TMG for methylation support, helps sustain cellular energy production and preserve healthy NAD+ metabolism over time.*6,9,10
What Makes Ours Better?
- Dual-Pathway NAD+ Support: Combines NMN and NR to enhance both intracellular and systemic NAD+ synthesis.*1,2
- Methylation-Enhanced: Includes 300 mg TMG per serving to maintain methylation balance and support healthy clearance of NAD+ metabolites.*6
- Targeted Liver Support: Supplies key nutrients that drive hepatic detoxification and help restore balance.*
- Clinically Supported Dosing: Delivers 1000 mg of NAD+ precursors per serving, reflecting levels used in human studies demonstrating improvements in cellular and metabolic function.*3-5
- Synergistic Design: Developed to activate multiple longevity mechanisms — from NAD+ synthesis and recycling to sirtuin and AMPK activation.*10
The ProHealth Difference
- Doctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts.
- Triple Lab Tested: Verified three times by independent labs for purity and potency.
- Full Transparency: Third-party test results published online for complete confidence.
- USA Manufactured: Proudly manufactured in the USA in FDA-registered, GMP-certified facilities since 1988.
- 100-Day Risk-Free Guarantee: If you’re not fully satisfied, we’ll refund your purchase in full.
A Word from our Chief Science Officer
"People tend to fall into camp NMN or camp NR. But why not do both? These two forms of vitamin B3 act at different points in the NAD+ pathway, working together to sustain NAD+ levels across multiple tissues. Used in combination, they provide broader support for the entire NAD+ metabolome."
Ingredient Info
Nicotinamide Mononucleotide (NMN): A vitamin B3 derivative and essential precursor in the NAD+ production pathway.*
Nicotinamide Riboside (NR): A vitamin B3 derivative and essential precursor in the NAD+ production pathway.*
Trimethylglycine (TMG): A natural methyl donor that supports NAD+ metabolism and maintains homocysteine balance.*
References:
- Huang H. Front Aging. 2022;3:851698.
- Orr ME et al. GeroScience. 2024;46(1):665-682.
- Kim M et al. Nutrients. 2022;14(4):755.
- Janssens GE et al. Nat Aging. 2022;2(3):254-263.
- Nascimento EBM et al. J Clin Endocrinol Metab. 2021;106(5):1437-1447.
- Arumugam MK et al. Biology. 2021;10(6):456.
- Yi L et al. GeroScience. 2023;45(1):29-43.
- Mehmel M et al. Nutrients. 2020;12(6):1616.
- Radenkovic D et al. Pharmaceuticals (Basel). 2020;13(9):247.
- López-Otín C et al. Cell. 2023;186(2):243-278.
| Supplement Facts | ||
|---|---|---|
| Serving Size: 3 Capsules | ||
| Servings Per Container: 30 | ||
| Amount Per Serving | %DV | |
| Nicotinamide Mononucleotide (NMN) | 500 mg | † |
| Nicotinamide Riboside (as NR Hydrogen Malate) |
500 mg | † |
| Trimethylglycine (TMG) | 300 mg | † |
| † Daily Value (DV) not established | ||
REV.09.25
- OTHER INGREDIENTS: Hypromellose (capsule), rice flour.
- SUGGESTED DAILY USE: Take three (3) capsules per day, with or without food, preferably in the morning.
- CAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.
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4.5 ★★★★★
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Product Reviews
★★★★★ 5
An Informative Introduction Based on Current Academic Studies of Western Esotericism
Format: Hardcover
This introductory text is the fruit of a fairly new field of recognized academic studies which developed as a result of the pioneering literary efforts of scholars such as D. P. Walker (1914 - 1985) and Frances A. Yates (1899 - 1981) who took the subject of Western esotericism seriously rather than denigrate it as an area filled with superstition and irrationalism as many earlier scholars in different specialized fields had done. Other scholars of esotericism who have contributed to this growing field include but are not limited to Henry Corbin, Francois Secret, Antoine Faivre, Arthur Versluis, Joscelyn Godwin, and Wouter Hanegraaff, the last being the senior editor of the landmark Dictionary of Gnosis and Western Esotericism (2005), a collaborative effort by many scholars. Goodrick-Clarke is also a recognized scholar in this field and introduces it to the reader in his own introduction which also addresses the question of how esotericism is defined by those dedicated to studying it.
As clarified in the introduction, Western esotericism is rooted in the Hellenistic philosophy of classical paganism as expressed in Alexandrian Hermeticism, Neoplatonism, and Gnosticism which have syncretized with the three Abrahamic religions of Judaism, Christianity and Islam, leaving vital traces within each. Through the Italian Renaissance, a Hermetic revival occurred as a result of the rediscovery of ancient texts which further resulted in the development of magic, astrology, alchemy, and Cabala through prominent individuals such as Marcilio Ficino, Pico della Mirandola, Johannes Reuchlin, Johann Trithemius, Henry Cornelius Agrippa, John Dee, and Paracelsus, each given significant attention. The development of German Naturphilosophie, Christian theosophy through Jacob Boehme and his followers (such as Gichtel, Pordage and Law), and Pietism are also covered before thoroughly introducing us to Rosicrucianism in the early 17th century, high-grade Freemasonry and Illuminism in the 18th century, and the ideas and practices of Emanuel Swedenborg and Franz Anton Mesmer which significantly impacted esotericism.
Within the context of Rosicrucianism, the content of the manifestos are discussed along with Johann Valentin Andreae and the Tubingen Circle; in England, Michael Maier, Robert Fludd, and Comenius and the Origins of the Royal Society are covered. The impact of Rosicrucianism and theosophy on Freemasonry are explored as well as the following types of Freemasonry: "Scottish" and Chivalric, German Templar, and Egyptian. Within the context of Freemasonry and Illuminism, the following are also discussed: Martines de Pasqually and the Elect Coens, Louis Claude de Saint-Martin, Martinesism, Martinism, Willermozism, The Illumines of Avignon, and Count Cagliostro.
Not only are the ideas of Swedenborg and Mesmer presented but also how they contributed to spiritualism and healing movements in the 19th century, including the United States which birthed Andrew Jackson Davis as the main theologian for spiritualism; Phineas Parkhurst Quimby, Warren Felt Evans and others who developed the New Thought Movement; and Mary Baker Eddy who founded Christian Science. A separate chapter is dedicated to ritual magic from 1850 to the present. Within this chapter, one is introduced to Eliphas Levi and the French Occult Revival, the Hermetic Order of the Golden Dawn and its members, and special attention is given to the contributions of A. E. Waite, Aleister Crowley and Thelemic magick, and Dion Fortune and the Inner Light. I was, however, disappointed to see the section on Crowley end with the following: "Gerald Gardner (1884 - 1964), the founder of modern witchcraft, introduced Crowleyan magick into the neopagan Wiccan movement." For a better understanding of the influential role of Crowley and ritual magic, including the grimoires, on Wiccan practices, I recommend Wicca: Magickal Beginnings (2008) by Sorita d'Este and David Rankine.
Helena Blavatsky and her Theosophical Society are given a separate chapter which expounds on her influences, travels, developing doctrines, and legacy. The last chapter titled "Modern Esotericism and New Paradigms" discusses theosophical heirs such as Annie Besant, Charles W. Leadbeater, and Rudolph Steiner (who developed his own religious system called "Anthroposophy"). It also has a section on Fourth Way Groups, introducing Gurdjieff and Ouspensky. Additionally, it covers the scientization of esotericism, New Age science, and Carl Jung's influence on esotericism. One individual I would have liked to see introduced within the context of Steiner is Valentin Tomberg who anonymously wrote Meditations on the Tarot: A Journey into Christian Hermeticism which is recognized by some, including esoteric scholar Antoine Faivre, as a masterpiece of 20th century esoteric/mystical literature.
Goodrick-Clarke's book not only includes valuable footnotes and recommendations for further reading for each chapter, but also includes a helpful index as well as over 30 illustrations comprised of portraits, diagrams, plates, charts and other relevant pictures to supplement the text. This historical introduction to Western esotericism deserves wide readership.
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Reviewed in the United States on February 26, 2009
★★★★★ 5
The Tradition Lives
Format: Hardcover
Throughout the Christian experience, Christianity has been a religion of the heart, perhaps best represented by the exoteric outer symbol and ritual of the Tradition. However, the Spirit will not go lacking, and there have been those individualistic and Protestant minded folks who have injected the Christian experience with Pagan influence in order to better satisfy the mind. Sources have included the towering Plato and Plotinus, while the Egyptian influence has been the quiter yet rangier philosophy of Hermes Trismegistus. Whereever the Christian Revelation has intersected with this Greek and Egyptian Rationalism, the product has resulted in Western Esotericism. The Tradition has quietly lived through millenia of possible persecution, martyrdom and certainly marginalization, yet has survived all the same. This book puts a glass to this Tradition and puts it in perspective, and expertly in my view. Major players are highlighted and minor counterparts are covered as well. Each participant, whether it by Mirandola compiling the Christian Kabbalah, or Paracelsus pushing past Galen to bring medicine to the door step of empiricism, all have added their own unique vision to the bigger picture of Western Esotericism.
Though the Tradition has it's roots in Egyptian and Greek Mystery Schools, it has been preserved, since the fall of the Roman Empire by Secret Societies such as Rosicrucianism, Freemasonry and even Theosophy and proves to be a viable option yet today for those who seek a deeper more inner sacred experience than what perhaps their outer religious profession provides.
Wondering?
This is a good place to start.
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Reviewed in the United States on January 2, 2009
★★★★★ 4
Serious[ly]
Format: Hardcover
This book is exactly what the title claims - a historical introduction. While although the author doesn't go into a great deal of depth, he more than makes up for it in breadth.
The author starts with an attempt at defining what exactly esotericism is. After that, the book is arranged chronologically, starting with Hellenistic esotericism and proceeding through the Renaissance, the Enlightenment and up to the present. Each chapter centers on an individual or group of individuals who were influential thinkers in their time and place. At the end of each chapter, there is a list of books for further study, much like a textbook.
It is serious; it is scholarly. It is most definitely not silly. If you are at all interested in a "Third Way", which is neither mainstream religion nor strictly empirical "scientism", this may be a gooding jumping-off point for you, as it was for me.
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Reviewed in the United States on February 18, 2014
★★★★★ 5
An amazing book that teaches a great history
Format: Kindle
This is a great book that takes the reader on an amazing journey through a part of Western history that is rarely taught.
This book teaches the other side of the development of Western religion and after reading this book I now have a knew light on previous theological education.
It is easy to understand but does not compromise on scholastic research and standards.
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Reviewed in the United States on March 12, 2014
★★★★★ 5
Probably The Best Introduction to Western Esotericism Available
Format: Hardcover
I recently completed my MA in Western Esotericism at the University of Exeter and studied under Nicholas Goodrick-Clarke. He is the Director of the Exeter Centre for the Study of Esotericism (EXESESO) at the University of Exeter. This book is structured in the same fashion as the MA program at Exeter and provides a comprehensive overview of the key topics in the field of Western esotericism. The book is chronological and begins in ancient Alexandria, through the Italian Renaissance, post-Reformation Germany and into the Age of Enlightenment. Goodrick-Clarke covers complex topics such as Hermeticism, Neo-Platonism, Alchemy, Freemasonry, Rosicrucianism and Theosophy but makes it understandable even to novice readers. The underlying theme behind the subject of Western esotericism is the continuity in the different schools of thought that can be traced though the two thousand period from ancient Alexandria to the present day. This is a subject that has been overlooked for many years due to its association with the occult and magic. Thanks to the work of Goodrick-Clarke and scholars such as Antoine Faivre and Wouter Hanegraaff it is now being given the respect it deserves. This is an excellent starting point for anyone interested in learning more.
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Reviewed in the United States on October 24, 2011