KL Recombinant Rabbit mAb (S-2245-169)
SKU: 77746605292

KL Recombinant Rabbit mAb (S-2245-169)

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Description

KL Recombinant Rabbit mAb (S-2245-169)Product Specification Host Rabbit Antigen KL Synonyms Klotho Immunogen Synthetic Peptide Location Secreted, Cell membrane Accession Q9UEF7 Clone Number S 2245 169 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Jurkat, K562, mouse kidney, mouse testis, rat kidney, rat testis Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%

Product Specification


Host Rabbit
Antigen KL
Synonyms Klotho
Immunogen Synthetic Peptide
Location Secreted, Cell membrane
Accession Q9UEF7
Clone Number S-2245-169
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu, Ms, Rt
Positive Sample Jurkat, K562, mouse kidney, mouse testis, rat kidney, rat testis
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
IHC-P 1:1000 Hu, Ms, Rt

Background

KL protein, also known as α-Klotho, is a type-I single-pass transmembrane protein encoded by the KL gene on chromosome 13, featuring a short intracellular tail and a large extracellular region composed of tandem KL1 and KL2 glycosidase-like domains that can be proteolytically cleaved by ADAM10 and other proteases to release a soluble, circulating hormone-like form. Initially discovered as an aging-suppressor, KL functions as a coreceptor for FGF23 to regulate phosphate, calcium, and vitamin D metabolism, while its soluble form modulates insulin/IGF-1 and Wnt signaling, suppresses oxidative stress and inflammation, and enhances synaptic plasticity and cognition; consequently, KL overexpression extends lifespan and improves healthspan in mice, whereas its deficiency accelerates aging phenotypes such as arteriosclerosis, osteoporosis, sarcopenia, and cognitive decline, and human KL variants are associated with hypertension, chronic kidney disease, and age-related disorders .

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SKU: 77746605292

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4.6 ★★★★★
Based on 1756 reviews
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Product Reviews
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Verified Purchase
Nana V
Bozeman, US
★★★★★ 1
Wobbly
Size: 38"Height × 14" Wide
Not sturdy
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 28, 2026
R
Verified Purchase
R
Belleville, US
★★★★★ 5
Strong legs, somewhat industrial but trendy also
Size: side table leg
Good legs, some what utilitarian or industrial, they are strong as they are made out of pipe, and assembly is fairly easy once you get the idea of how it goes together. They are roughly 1.5 feet across maybe a bit less adjustable height on each leg, if you have wood floors you may want to put a pad under each leg as they are full metal pipes. Pretty interesting idea and does not cost much.
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Reviewed in the United States on May 31, 2026
N
Verified Purchase
Nc
Birmingham, US
★★★★★ 4
Pretty good, take your time and install it well
Size: side table leg
Materials are pretty solid, but once assembled it’s not as sturdy as you would think it should be since the material itself was solid, i say give them a chance, everything out there that’s similar is way over priced
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Reviewed in the United States on May 4, 2026
R
Verified Purchase
Roberta Mayes
Omaha, US
★★★★★ 5
Heavy duty legs for table.
Size: side table leg
Perfect legs for a table I am having made. I have an cottonwood slice. It's heavy and needed something substantial. These are perfect.
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Reviewed in the United States on May 25, 2026
R
R. Moheban
Omaha, US
★★★★★ 5
Robust pipe & fittings with a beautiful, smooth black finish
Size: side table leg
This set of pipe & fittings for use as low table legs is heavy duty and aesthetically pleasing. Especially when the pieces are handled, the tactile sensation is much nicer than with plumbing steel pipe because this product is beautifully finished smooth. The black pipes are quite smooth as well as the fittings. The pieces are all also pretty robust, though the wall thicknesses are less than in pipe for pressurized water systems. Of course that makes sense as this product does not need to hold fluid pressure. In my view they got the heaviness factor of this product just right; it's not as heavy or robust as black pipe used in natural gas supplies, but still robust and pretty heavy. Assembled, this product is absolutely stiff and unyielding for a solid table that could hold a man's weight easily. The feet utilize a brilliant scheme so that each foot can be independently adjusted for an uneven floor. Thus a level table on an uneven floor is easily accomplished. The feet simply extend the effective leg length by screwing counter-clockwise. To prevent any shifting at the threads adding some pipe compound or teflon tape may be advised. Even masking or duct tape might work as the idea is to just fill any gaps where male threads meet female threads. The four flanges at the tops of the legs provide a wide, solid surface for attaching the table top, with either hidden screws underneath or you could through-bolt a glass table top (provided you have the skill to drill glass!). I think this product would look great with a glass top. Assembly is quick and easy. The hardest part is drilling holes underneath the table top to accept screws. No pipe wrenches are needed as the pieces screw together by hand to an adequate tightness. If any doubt whether they are tightened enough have a strong person with grippy gloves finish. The "X" in the center attaches to the legs with a very clever machine screw system tightened with the included hex wrench. This is presumably because if tightened simply by screwing the fittings, the point of snugness would not likely be where the "T" fittings are exactly vertical. The maker has solved this problem so that you are assured that all legs will be in the perfect vertical position once everything is tight. The setup is also nice and rigid once tightened. This is a huge benefit of steel pipe projects; they are really solid. The black finish is clearly very durable, like a powder coat. It appears that it will provide excellent protection against rust. Coverage is complete; I found no dings or scratches anywhere on any piece. Overall this is a very well-designed product for function and aesthetics. Perfect for a beautifully renovated warehouse condo where an industrial vibe is desired in a rock-solid table that won't shift around. The smoothness of the pipe is top notch. I've used lots of pipe in projects, some of it actual water pipe and some decorative pipe such as this. I've never seen better quality decorative pipe as this maker put in the effort to finish it beautifully smooth. At currently $34.99 I find the price quite reasonable too.
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Reviewed in the United States on April 18, 2026

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