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Description
MelanA Recombinant Rabbit mAb (SDT-3352)Product Specification Host Rabbit Antigen MelanA Synonyms Melanoma antigen recognized by T cells 1; MART 1; Antigen LB39 AA; Antigen SK29 AA; Protein Melan A; MART1; MLANA Location Cytoplasm, Endoplasmic reticulum Accession Q16655 Clone Number SDT 3352 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms Positive Sample SK MEL 28, B16F0 Purification Protein A Concentration 0. 5mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | MelanA |
| Synonyms | Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A; MART1; MLANA |
| Location | Cytoplasm, Endoplasmic reticulum |
| Accession | Q16655 |
| Clone Number | SDT-3352 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms |
| Positive Sample | SK-MEL-28, B16F0 |
| Purification | Protein A |
| Concentration | 0.5mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms |
| IHC-P | 1:1000 | Hu, Ms |
| ICC | 1:500 | Hu, Ms |
Background
MelanA (also called MART-1) is a 13 kDa single-pass transmembrane protein encoded by the MLANA gene, expressed almost exclusively in melanocytes of the skin and retina, where it stabilizes and traffics the melanosomal glycoprotein gp100 to facilitate stage II melanosome biogenesis and melanin synthesis; its immunogenic 26-35 amino-acid fragment is presented on HLA class I molecules and constitutes one of the most frequent targets of circulating naïve CD8⁺ T cells, making the protein both a key histopathologic marker (detected by antibodies A103 or M2-7C10) for melanocytic tumors and a central component in experimental melanoma vaccines .
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