PE Mouse Anti-human HLA-ABC Antibody (S-R526)
SKU: 6469880279

PE Mouse Anti-human HLA-ABC Antibody (S-R526)

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Description

PE Mouse Anti-human HLA-ABC Antibody (S-R526)Product Specification Host Mouse Antigen HLA ABC Synonyms HLA class I histocompatibility antigen; A alpha chain; Human leukocyte antigen A (HLA A); HLA class I histocompatibility antigen; B alpha chain; Human leukocyte antigen B (HLA B); HLA class I histocompatibility antigen, C alpha chain; HLA Cw; Human leukocyte antigen C Location Cell membrane Accession P04439P01889P10321 Clone Number S R526 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM

Product Specification


Host Mouse
Antigen HLA-ABC
Synonyms HLA class I histocompatibility antigen; A alpha chain; Human leukocyte antigen A (HLA-A); HLA class I histocompatibility antigen; B alpha chain; Human leukocyte antigen B (HLA-B); HLA class I histocompatibility antigen, C alpha chain; HLA-Cw; Human leukocyte antigen C
Location Cell membrane
Accession P04439、P01889、P10321
Clone Number S-R526
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample human peripheral blood Leukocytes
Purification Protein A
Concentration 0.2 mg/ml
Conjugation PE
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1.25μl per million cells in 100μl volume Hu

Background

HLA-ABC (also termed HLA class I classical heavy chains A, B, and C) are 44 kDa type I transmembrane glycoproteins encoded within the major histocompatibility complex on chromosome 6p21.3; each non-covalently associates with the invariant light chain β2-microglobulin (12 kDa) to form a peptide-binding heterodimer that is constitutively expressed on nearly all nucleated cells. These molecules serve as the principal conduit for presenting endogenously derived 8–11-mer peptides to CD8⁺ cytotoxic T lymphocytes, thereby orchestrating immune surveillance against intracellular pathogens, tumors, and transplanted tissues. Polymorphic residues concentrated in the α1 and α2 domains create an extraordinary diversity (thousands of alleles catalogued in the IPD-IMGT/HLA database), which underpins population-level resistance to infection yet constitutes the primary barrier to solid-organ and hematopoietic stem-cell transplantation through allorecognition. Beyond antigen presentation, HLA-ABC interacts with NK-cell inhibitory receptors (KIR and LILRB1) to calibrate natural killer cell responses, and its surface levels are dynamically modulated by cytokines such as interferon-γ, viral immune evasion proteins (e.g., HIV Nef, CMV US2/US11), and oncogenic signaling pathways, making quantitative HLA-ABC expression a prognostic biomarker in cancer immunotherapy.

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SKU: 6469880279

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Zaya
Phoenix, US
★★★★★ 5
Perfect smell
Love Hawaiin products, they give me instant tropical vibes. Quick absorbing and instant skin softness
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Reviewed in the United States on December 20, 2025
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Miranda Smith
Port Orchard, US
★★★★★ 5
Love
I actually really like this lotion, nice quality for decent price and has a nice smell too.
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Reviewed in the United States on December 3, 2025
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Ashley Brooks
Carnegie, US
★★★★★ 5
Love the way this makes you shimmer and shine. It's absolutely beautiful.
Color: Light Rose Gold Body Glow, Color: Light Rose Gold Body Glow
This stuff is bomb! It is so good. It looks so good on the skin and it doesn't have a bad smell. It smells actually good. I would continue. I will continue to purchase this product. I love it that much!
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Reviewed in the United States on April 12, 2026
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LinaaTrejo
Phoenix, US
★★★★★ 5
Order it, you won’t regret it.
Color: Light Rose Gold Body Glow
Super glittery! Very pretty and love how it has a tint of color!
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Reviewed in the United States on April 4, 2026
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TeeShirtLing
Chelsea, US
★★★★★ 4
Pretty
Color: Light Rose Gold Body Glow
This stuff has a strong scent. Sort of beachy, sunscreen smell, which is not my favorite. It is definitely shimmery. I used this for a hawaiian themed party. It was pretty! It dried down fairly quickly. I did place a towel down in my car before I got in it just in case some of it came off the back of my legs and got all over the seat. I wear black pants to work most days, and didn't want a glitter butt every day.
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Reviewed in the United States on November 26, 2025

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