Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 7 - Jul 12
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
TAK1 Recombinant Rabbit mAb (S-2482-39)Product Specification Host Rabbit Antigen TAK1 Synonyms Mitogen activated protein kinase kinase kinase 7; Transforming growth factor beta activated kinase 1 (TGF beta activated kinase 1); MAP3K7 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession O43318 Clone Number S 2482 39 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample HEK 293, HeLa, A431, A549, NIH 3T3, C6, COS 7 Purification
Product Specification
| Host | Rabbit |
| Antigen | TAK1 |
| Synonyms | Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1 (TGF-beta-activated kinase 1); MAP3K7 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | O43318 |
| Clone Number | S-2482-39 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HEK-293, HeLa, A431, A549, NIH/3T3, C6, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt, Mk |
Background
TAK1 (MAP3K7) is a ubiquitously expressed serine/threonine kinase that acts as a central signaling hub by integrating cues from TGF-β, inflammatory cytokines (TNF-α, IL-1), pattern-recognition receptors (TLR, NOD-like receptors) and cellular stress to catalyze the activation of IKK and MAP2Ks (MKK3/6, MKK4/7), thereby driving the NF-κB, p38, JNK and ERK pathways that collectively regulate inflammation, innate and adaptive immunity, cell survival, differentiation and metabolic adaptation; its activity is tightly controlled through stimulus-inducible assembly with regulatory binding partners TAB1, TAB2 and TAB3 and by polyubiquitin scaffolds, and genetic or pharmacologic dysregulation of TAK1 is linked to inflammatory diseases, autoimmunity and cancer.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy