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Description
human bsep vesicle kit hek293Das Human BSEP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient die Bile Salt Export Pump (BSEP ABCB11) berexprimieren. BSEP ist der primre hepatische Efflux Transporter fr Gallensalze und ein zentrales Zielprotein in der Risikoabschtzung fr medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017) und EMA (2013) Leitlinien fr DDI Studien. Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich
Das Human BSEP Vesicle Kit enthält Inside-out Membranvesikel aus HEK293-Zellen, die transient die Bile Salt Export Pump (BSEP / ABCB11) überexprimieren. BSEP ist der primäre hepatische Efflux-Transporter für Gallensalze und ein zentrales Zielprotein in der Risikoabschätzung für medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017)- und EMA (2013) Leitlinien für DDI Studien.
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
Transporter-Profil
Name: BSEP, Bile Salt Export Pump, ABCB11, ATP-bindende Kassette Unterfamilie B Mitglied 11
Gen: ABCB11
ATP/AMP-Ratio: >10 (garantiert)
Gewebsexpression: Kanalikuläre Plasmamembran der Hepatozyten
Erkrankungen: Erbliche und medikamenteninduzierte Cholestase (DILI)
Bekannte Substrate: Taurocholat, Pravastatin, Taurolithocholyl-3-Sulfat, konjugierte monovalente Gallensalze
In stock: Human, Katze, Hund
Kit-Inhalt (100 Reaktionen)
- Vesikel-Vial (100 Reaktionen), BSEP überexprimierende HEK293-abgeleitete Vesikel
- AMP-ATP-Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Anwendungen
- allensalztransport-Inhibitionsstudien (Cholestase-Risikoabschätzung)
- Drug-Induced Liver Injury (DILI) Screening
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Substratidentifikation für hepatische Efflux-Transporter
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
Die Hemmung von BSEP ist ein etablierter Mechanismus der medikamenteninduzierten cholestatischen Leberschädigung. Die Bewertung der BSEP-Hemmung wird in den FDA (2017)- und EMA (2013)-DDI-Leitlinien als Teil des Transporter-Charakterisierungspakets für neue Molekülentitäten (NMEs) in der klinischen Entwicklung empfohlen.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
Verwandte Produkte
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
- Human MRP2 Vesicle Kit (C4PVK002) – for parallel hepatic efflux assessment
- Human BCRP Vesicle Kit (C4PVK006) – for complete efflux transporter panel
- ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
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4.3 ★★★★★
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Product Reviews
★★★★★ 1
horrible paper. pizza wheel track marks extremely visible and the paper gets all wavy from ink.
Size: 13"X19"
horrible paper. pizza wheel track marks left by printer guide wheels are extremely visible after printing, and the paper gets all wavy from being saturated with ink. I would most definitely call this paper defective in design. The gloss cannot be used in a printer, even though it is meant to be used in a printer. returned for refund.
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Reviewed in the United States on December 9, 2025
★★★★★ 5
Value for print
Size: 4"X6"
Yeams and yes. The print quality really depends on your printer and ink. It was awesome for my Epson eco tank but as good for my old inkjet HP.
Great value. Good thick paper. Dries kinda instantly (epson). Gloss is standard as advertized.
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Reviewed in the United States on December 16, 2025
★★★★★ 4
Overpriced for the amount given you should get at least a hundred for the price quality decent
Size: 8.5"X11"
Good paper but not worth the price they have the same quality paper but $5 cheaper elsewhere
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Reviewed in the United States on August 25, 2025
★★★★★ 5
Excelente
Size: 8.5"X11"
Perfecto para mi printer, buena calidad
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Reviewed in the United States on February 21, 2026
★★★★★ 5
Excellent Photo Paper — Beautiful Results
Size: 13"x19"
I love this A-SUB Premium Double Sided Photo Paper. The luster finish looks really nice, and prints come out sharp, clean, and professional-looking.
The double-sided design is also a huge plus. It feels sturdy, handles ink well, and gives photos a polished look without being overly glossy. It’s exactly the kind of paper that makes prints feel more premium.
Very happy with it and would absolutely buy it again.
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Reviewed in the United States on May 20, 2026
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